2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
    Neuronal Signaling
  4. Calcium Channel

Calcium Channel

Ca2+ channels; Ca channels

Calcium Channel

Related Products

PDF 4.86 MB

Calcium channel is an ion channel which displays selective permeability to calcium ions. It is sometimes synonymous as voltage-dependent calcium channel, although there are also ligand-gated calcium channels. Voltage-gated calcium (CaV) channels catalyse rapid, highly selective influx of Ca2+ into cells despite a 70-fold higher extracellular concentration of Na+. Some calcium channel blockers have the added benefit of slowing your heart rate, which can further reduce blood pressure, relieve chest pain (angina) and control an irregular heartbeat.

Calcium Channel Isoform Specific Products:

Calcium Channel Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W032013S1
    1-Octanol-d2
    1-Octanol-d2 is the deuterium labeled 1-Octanol. 1-Octanol (Octanol), a saturated fatty alcohol, is a T-type calcium channels (T-channels) inhibitor with an IC50 of 4 μM for native T-currents. 1-Octanol is a highly attractive biofuel with diesel-like properties.
    1-Octanol-d<sub>2</sub>
  • HY-B0280S
    Ranolazine-d5
    		Inhibitor
    Ranolazine-d5 is the deuterium labeled Ranolazine. Ranolazine (CVT 303) is an anti-angina drug that achieves its effects by inhibiting the late phase of inward sodium current (INa and IKr with IC50 values of 6 μM and 12 μM, respectively) without affecting heart rate or blood pressure (BP). Ranolazine is also a partial fatty acid oxidation (FAO) inhibitor. Antianginal agent.
    Ranolazine-d<sub>5</sub>
  • HY-N0081A
    (-)-Praeruptorin A
    		Inhibitor
    (-)-Praeruptorin A is a nature product that could be isolated from the roots of Peucedanum praeruptorum Dunn. (-)-Praeruptorin A relaxes ileum and tracheal smooth muscles by activating NO/cGMP signaling pathway. (-)-Praeruptorin A has dramatically therapeutic effects on hypertension mainly through acting as a Ca2+-influx blocker.
    (-)-Praeruptorin A
  • HY-B0612DS
    (R)-Lercanidipine-d3 hydrochloride
    		Inhibitor 99.94%
    (R)-lercanidipine D3 hydrochloride is a deuterium labeled (R)-Lercanidipine hydrochloride. (R)-Lercanidipine-d3 (hydrochloride), the R-enantiomer of Lercanidipine, is a calcium channel blocker.
    (R)-Lercanidipine-d<sub>3</sub> hydrochloride
  • HY-B0233S1
    Isradipine-d6
    Isradipine-d6 is the deuterium labeled Isradipine. Isradipine (PN 200-110) is an orally active L-type calcium channel blocker. Isradipine, as a powerful peripheral vasodilator, is a dihydropyridine calcium antagonist with selective actions on the heart as well as the peripheral circulation. Isradipine is a potentially viable neuroprotective agent for Parkinson's disease.
    Isradipine-d<sub>6</sub>
  • HY-W721517
    Gabapentin-d10
    Gabapentin-d10 is the deuterium labeled Gabapentin (HY-A0057). Gabapentin is a potent, orally active P/Q type Ca2+ channel blocker. Gabapentin inhibits neuronal Ca2+ influx and reduction of neurotransmitter release. Gabapentin is a GABA analog that can be used to relieve neuropathic pain.
    Gabapentin-d<sub>10</sub>
  • HY-148866
    Cavα2δ1&NET-IN-3
    		Inhibitor
    Cavα2δ1&NET-IN-3 (example 216) is an inhibitor of the subunit α2δ of voltage-gated calcium channels (VGCC) and noradrenaline transporter (NET). Cavα2δ1&NET-IN-3 has Kis of 100-500 nM for human α2δ-1 subunit of Cav2.2 calcium channel and NET, respectively.
    Cavα2δ1&NET-IN-3
  • HY-106810A
    Naltiazem hydrochloride
    		Antagonist
    Naltiazem (Ro 23-6152) hydrochloride is a thiazepinone-type calcium antagonist. Naltiazem hydrochloride inhibits platelet aggregation in vitro and in vivo.
    Naltiazem hydrochloride
  • HY-113328R
    Aminoadipic acid (Standard)
    Aminoadipic acid (Standard) is the analytical standard of Aminoadipic acid. This product is intended for research and analytical applications. Aminoadipic acid is an orally active lysine oxide derivative. Aminoadipic acid induces ROS generation, increases free Ca2+, decreases SOD, and activates TXNIP/NLRP3 pathway. Aminoadipic acid has pro-inflammatory effects. Aminoadipic acid can be used in atherosclerosis research[1][2][3][4].
    Aminoadipic acid (Standard)
  • HY-17007S
    Saquinavir-d9
    Saquinavir-d9 (Ro 31-8959-d9) is the deuterium labeled Saquinavir (HY-17007). Saquinavir (Ro 31-8959) is an orally active HIV protease inhibitor that can be used in the research of AIDS. Saquinavir also has anti-inflammatory activity and can induce apoptosis of human red blood cells.
    Saquinavir-d<sub>9</sub>
  • HY-167925
    Rec 15/2615
    		Agonist
    Rec 15/2615 is a potent α(1)-adrenergic agonist that stimulates small cholangiocyte proliferation through the activation of calcium-dependent signaling pathways.
    Rec 15/2615
  • HY-15293
    JTV-519
    		Inhibitor
    JTV-519 (K201) is a Ca2+-dependent blocker of sarcoplasmic reticulum Ca2+-stimulated ATPase (SERCA) and a partial agonist of ryanodine receptors in striated muscle. Antiarrhythmic and cardioprotective properties.
    JTV-519
  • HY-142050
    (R)-IDHP
    (R)-IDHP is an isomer of IDHP, a salvia metabolite that exerts vasorelaxant effects by inhibiting Ca2+ release and Ca2+ inward flow in voltage-dependent and receptor-operated calcium channels in vascular smooth muscle cells. IDHP is used in studies of cardiovascular disease.
    (R)-IDHP
  • HY-P10898
    GeX-2
    		Antagonist
    GeX-2 is a truncated analogue of αO-conotoxin. GeX-2 activates GABAB receptor. GeX-2 inhibits α9α10 nAChR and CaV2.2 channels. GeX-2 alleviates pain in the rat model of chronic constriction injury.
    GeX-2
  • HY-149305
    PptT-IN-4
    		Inhibitor
    PptT-IN-4 (Compound 3a) is a PptT inhibitor (IC50: 0.71 μM). PptT-IN-4 inhibits Mtb H37Rv with a MIC value of 42 μM. PptT-IN-4 also inhibits hERG, hCav1.2, and hNav1.5 channels with IC50s of 11 μM, 8.1 μM, 6.9 μM respectively.
    PptT-IN-4
  • HY-B1837A
    β-Cyfluthrin
    		Inhibitor 99.94%
    β-Cyfluthrin (beta-Cyfluthrin) is a type II synthetic pyrethroid and also an active ingredient of many insecticide products used for pestsin agriculture. β-Cyfluthrin is a neurotoxicant and affects calcium concentration in nervous tissue by inhibiting Ca2+ ATPase involved in calcium transport.
    β-Cyfluthrin
  • HY-116330
    Hyperforin
    		Modulator
    Hyperforin is a transient receptor canonical 6 (TRPC6) channels activator. Hyperforin modulates Ca2+ levels by activating Ca2+-conducting non-selective canonical TRPC6 channels and triggers adipose tissue thermogenesis via the Dlat-AMPK signaling axis to suppress obesity. Hyperforin also shows diverse pharmacological activities including anti-depression, anti-tumor, anti-dementia, anti-diabetes. Hyperforin modulates γδ T cells to secret IL-17α, improves Imiquimod (HY-B0180)-induced psoriasis-like mice model.
    Hyperforin
  • HY-156669
    Calcium Channel antagonist 4
    Calcium Channel antagonist 4 (compound 189) is an inhibitor of voltage-gated calcium channels with an IC50 value of 5-20μM.
    Calcium Channel antagonist 4
  • HY-123435
    RWJ 22108
    		Inhibitor
    RWJ 22108 is a bronchoselective calcium channel blocker, with the IC50 of 5.7 nM in calcium-dependent contraction of canine bronchiolar smooth muscle.
    RWJ 22108
  • HY-113308AS2
    Taurolithocholic acid-d4-1 sodium
    		Agonist
    Taurolithocholic acid-d4-1 (sodium) is the deuterium labeled Taurolithocholic acid. Taurolithocholic acid sodium salt, a potent cholestatic agent, is a potent Ca2+ agonist.
    Taurolithocholic acid-d<sub>4</sub>-1 sodium
Cat. No. Product Name / Synonyms Application Reactivity
Calcium Channel Isoform Comparison

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.